Catalysis for the Twenty-First Century Chemical Industry

We are introducing olefin metathesis reaction into everyday industrial practice

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Latest updates!

Last events
  • New PostDoc (ENG, PL) position is available in Grela's group from the FNP TEAM-TECH programme. The Applicants must complete and submit the Application Form (PDF, DOC) and ask their former supervisors for submission of Recommendation Letters (PDF, DOC). For more information on the formal requirements see Application Form and documents available at FNP site [PL version]. For information on the responsibilities of PostDoc check here. Deadline for applications is 31.07.2019. Please apply!

  • New PostDoc (ENG, PL) position is available in Grela's group from the FNP TEAM-TECH programme. The Applicants must complete and submit the Application Form (PDF, DOC) and ask their former supervisors for submission of Recommendation Letters (PDF, DOC). For more information on the formal requirements see Application Form and documents available at FNP site [PL version]. For information on the responsibilities of PostDoc check here. Deadline for applications is 05.05.2019. Please apply!

  • New PostDoc (ENG, PL) position is available in Grela's group from the FNP TEAM-TECH programme. The Applicants must complete and submit the Application Form (PDF, DOC) and ask their former supervisors for submission of Recommendation Letters (PDF, DOC). For more information on the formal requirements see Application Form and documents available at FNP site [PL version]. For information on the responsibilities of PostDoc check here. Deadline for applications is 10.03.2019. Please apply!

  • Our team presented new results at 50. Symposium on Catalysis in Prague, Czech Republic on 5-6 November 2018.

  • Michał Patrzałek visited prof. Hynek Balcař's laboratory in Prague, Czech Republic for a two week long internship in November 2018.

  • New PostDoc (ENG, PL) position is available in Grela's group from the FNP TEAM-TECH programme. The Applicants must complete and submit the Application Form (PDF, DOC) and ask their former supervisors for submission of Recommendation Letters (PDF, DOC). For more information on the formal requirements see Application Form and documents available at FNP site [PL version]. For information on the responsibilities of PostDoc check here. Deadline for applications is 03.02.2019. Please apply!

  • New PostDoc (ENG, PL) position is available in Grela's group from the FNP TEAM-TECH programme. The Applicants must complete and submit the Application Form (PDF, DOC) and ask their former supervisors for submission of Recommendation Letters (PDF, DOC). For more information on the formal requirements see Application Form and documents available at FNP site [PL version]. For information on the responsibilities of PostDoc check here. Deadline for applications is 19.12.2018. Please apply!

  • New Student (ENG, PL) positions are available in Grela's group from the FNP TEAM-TECH programme. Deadline for applications is 07.10.2018. Please apply!

  • New Student (ENG, PL) position is available in Grela's group from the FNP TEAM-TECH programme. Deadline for applications is 22.03.2018. Please apply!

  • New PhD student (ENG, PL) position is available in Grela's group from the FNP TEAM-TECH programme. The Applicants must complete and submit the Application Form (PDF, DOC) and ask their former supervisors for submission of Recommendation Letters (PDF, DOC). For more information on the formal requirements see Application Form and documents available at FNP site [PL version]. Deadline for applications is 22.03.2018. Please apply!

  • Paweł Krzesiński defended his BSc Thesis "Synteza nowego, podwójnie N-tagowanego katalizatora rutenowego i jego wykorzystanie w reakcjach metatezy olefin". Congratulations!

  • Two new students will join our team: Jakub and Johannes (from October), welcome in the group!

  • New two Student (ENG, PL) positions are available in Grela's group from the FNP TEAM-TECH programme. Deadline for applications is 31.12.2017. Please apply!

  • Beilstein Organic Chemistry Symposium 2017 Tomorrow's Catalysis for Research and Industry is an occasion for a meeting with project partners: Prof. Kappe, Dr. Balcar and Apeiron Synthesis S.A. team members.


    TEAM-TECH team members and project partners

    TEAM-TECH team members and project partners from left: Michał Patrzałek, Hynek Balcar, Katarzyna Kaczanowska, Anna Kajetanowicz, Krzysztof Skowerski, Michał Bieniek, Oliver Kappe, Karol Grela.

  • Beilstein Organic Chemistry Symposium 2017 Tomorrow's Catalysis for Research and Industry is an occasion for a meeting of our PhD student Michał Patrzałek with his mentor Dr. Balcar.


    Mr Patrzałek and his mentor Dr. Balcar

    From left Hynek Balcar and Michał Patrzałek.

  • Karol Grela and Anna Kajetanowicz are scientific organizers of Tomorrow's Catalysis for Research and Industry Beilstein Organic Chemistry Symposium 2017 which took place from 24 - 26 October 2017 in Potsdam, Germany.


    Organizers of Beilstein Symposium

    Organizers from left: Anna Kajetanowicz, Michael Penk and Karol Grela.

  • Prof. Olivier Kappe visited our laboratories in Warsaw in October 2017.


    TEAM-TECH team members and Prof. Kappe

    TEAM-TECH team members and Prof. Kappe from left: Anna Marczyk, Olivier Kappe, Michał Patrzałek, Mariusz Milewski, Wojciech Nogaś, Anupam Jana and Nirmalya Mukherjee.

  • New two Student positions are available in Grela's group from the FNP TEAM-TECH programme. Deadline for applications is 31.10.2017. Please apply!

  • Karol Grela and Anna Kajetanowicz are organizers of BEILSTEIN ORGANIC CHEMISTRY SYMPOSIUM 2017 entitled “TOMORROW'S CATALYSIS FOR RESEARCH AND INDUSTRY”. The symposium will take place at Avendi Hotel am Griebnitzsee, Potsdam, Germany form 24 to 26 October 2017. For more information please visit the website.

  • New PostDoc was selected. Artur, welcome in the group!

  • Our first paper was highlighted by RSC with a prestigious front cover. See: our Publications List for more details.

  • New PostDoc (ENG, PL) positions are available in Grela's group from the FNP TEAM-TECH programme. The Applicants must complete and submit the Application Form (PDF, DOC) and ask their former supervisors for submission of Recommendation Letters (PDF, DOC). For more information on the formal requirements see Application Form and documents available at FNP site [PL version]. For information on the responsibilities of PostDoc check here. Deadline for applications is 31.08.2017. Please apply!

  • New students were selected. Ola, Agnieszka, Paweł, welcome in the group!

  • New four student (ENG, PL) positions are available in Grela's group from the FNP TEAM-TECH programme.

  • New PostDoc was selected. Anupam, welcome in the group!

  • New PhD students were selected. Ania, Wojtek, Mariusz, Michał, welcome in the group!

  • New four PhD student (ENG, PL) positions are available in Grela's group from the FNP TEAM-TECH programme. The Applicants must complete and submit the Application Form (PDF, DOC) and ask their former supervisors for submission of Recommendation Letters (PDF, DOC). For more information on the formal requirements see Application Form and documents available at FNP site [PL version]. Deadline for applications is 18.12.2016. Please apply!

    Project

    The aim of the Team Tech project, supported by the Foundation for Polish Science, is to remove existing limitations in the use of catalysis in modern chemical production. For example, the revolutionary method of obtaining organic compounds, the catalytic olefin metathesis, although potentially powerful and innovative, is very rarely used in the industrial production of complex organic compounds.

    The project's goal is to break through a number of barriers that currently prevent the widespread application of this reaction in chemical production, intensify it, make it more environmentally-friendly, more selective, and more accessible.

    Potential solution for this will include the development of new immobilized ("anchored") ruthenium complexes as metathesis catalysts. The same approach will be adopted in the case of potentially very promising gold catalysis.

    Based on the most recently published opinions and our own experience of working with the chemical industry, we have identified a number of problems that, as we believe, will result in much wider use of modern organic synthesis methods (eg, olefin metathesis, gold catalysis) in industrial practice.

    Partners

    The project is a joint effort of international european partners.

    Dr. Hynek Balcar : Dr. Balcař works in the J. Heyrovský Institute of Physical Chemistry of the ASCR and he is the well-known expert in the field of zeolites.

    Dr. Michał Chmielewski : he is working i.e. on Metal Organic Frameworks (MOFs) as catalysts for organic reactions, Supramolecular chemistry of anions – molecular receptors, sensors and transporters for anions, Photoswitchable receptors and catalysts and Dynamic combinatorial chemistry.

    Prof. Dr. Andreas Kirschning : Prof. Andreas Kirschning studied chemistry at the University of Hamburg and at Southampton University (UK). In Hamburg, he joined the group of Prof. Ernst Schaumann and received his PhD in 1989 working in the field of organosilicon chemistry. After a postdoctoral stay at the University of Washington (Seattle, USA) with Prof. Heinz G. Floss, he started his independent research at the Clausthal University of Technology in 1991, where he finished his habilitation in 1996. In 2000 he moved to the Leibniz University of Hannover. His research interests cover structure elucidation as well as the semi-, total and mutasynthesis of natural products, biomedical biopolymers, and synthetic technologies (solid-phase assisted synthesis, microreactors and inductive heating).

    Prof. Dr. Olivier Kappe : C. Oliver Kappe is Professor of Chemistry at the University of Graz (Austria) and Scientific Director of Center for Continuous Flow Synthesis and Processing (CC FLOW) at the Research Center Pharmaceutical Engineering GmbH (RCPE). He received his diploma (1989) and his doctoral (1992) degrees in organic chemistry from the University of Graz where he worked with Gert Kollenz on cycloaddition and rearrangement reactions of acylketenes. After periods of postdoctoral research work on reactive intermediates and matrix isolation spectroscopy with Curt Wentrup at the University of Queensland in Brisbane, Australia (1993-1994) and on synthetic methodology/alkaloid synthesis with Albert Padwa at Emory University in Atlanta, USA (1994-1996), he moved back to the University of Graz in 1996 to start his independent academic career. He obtained his „Habilitation“ in 1998 in organic chemistry and was appointed Associate Professor in 1999. From 2011 till 2016 he held the position of Professor of „Technology of Organic Synthesis“ (Organische Synthesetechnologie) at the Institute of Chemistry at the University of Graz. Professor Kappe has an extensive general experience and a 25 year track record in synthetic and physical organic chemistry, process intensification using batch microwave technology and flow chemistry/microreaction technology, communicated in over 380 scientific publications (Research ID, WoS h-Index 69). For the past decade the focus of his research has been directed towards flow chemistry/microreaction technology, encompassing a wide variety of synthetic transformations and experimental techniques. His research group is actively involved in projects dealing with API synthesis and manufacturing, employing a number of different enabling and process intensification technologies. For his innovative work in microwave chemistry he received the 2004 Prous Science Award from the European Federation for Medicinal Chemistry and the 2010 100.000 € Houska Prize in addition to a number of other awards. In 2015 he was named Fellow of the Royal Society of Chemistry.

    Dr. Eng. Michał Bieniek — Apeiron Synthesis S.A : Dr. Michal Bieniek is a co-founder and the CEO of Apeiron Synthesis, our industrial partner. He is a co-inventor of six patents and patent applications and the author of over 20 scientific publications in the areas of novel metathesis catalysts and their commercial applications. Michal earned an M.Sc. with honors from Warsaw University of Technology and a Ph.D. in Chemistry from the Institute of Organic Chemistry, Polish Academy of Sciences. His training in organic chemistry includes research fellowships at leading laboratories in France, Germany and the Netherlands.

    Karol Grela

    Leader

    Prof. Karol Grela graduated with M.Sc. degree in Organic Chemistry from Chemistry Department, Warsaw University of Technology and obtained Ph.D. form Institute of Organic Chemistry, Polish Academy of Science in 1998. He subsequently held postdoctoral position at the Max-Planck-Institute. He came back to Polish Academy of Science and finished habilitation in 2003 and became Professor in 2008. Since 2008 he works at the University of Warsaw where he is an academic teacher and directs Organometallic Synthesis Laboratory (OSL). He is still associated with Polish Academy of Sciences where he leads research group too. His main achievements are: the Minister of Science and Higher Education Prize (2010), Foundation for Polish Science Prize (2014), French-Polish Prize awarded by the French Chemical Society (2015) and Stanisław Kostanecki Medal of Polish Chemical Society (2016). Although current research of OSL is mainly focused on transition metal complexes, with special emphasis on olefin metathesis catalysts, our specialization cannot be called a truly organometallic or coordination chemistry. Instead, our research is mainly concerned on application of these complexes in organic synthesis of natural products and pharmaceutically relevant compounds, in sustainable production, applications of aqueous media, etc. Our group is developing new ruthenium olefin metathesis catalysts of enhanced properties. We have found that changing the electron density at the Ru-chelating oxygen or nitrogen of Hoveyda or Grubbs type complexes has direct impact on the both catalyst activity and stability. Such ruthenium catalysts have found applications in target-oriented synthesis and polymerization. Especially, the stable 5-nitro-substituted catalyst introduced by us, exhibits impressive activity in ring-closing (RCM), cross (CM) and enyne-metathesis. As a result, this catalyst has found many successful applications in target oriented syntheses and in the pharmaceutical industry.  Various other catalysts have been later described, some are commercially available from Apeiron Sythensis, Umicore, TCI and Strem, Chemicals Inc.

    The Team

    The team consists of four PHD students and a post-doc, young specialists in olefin metathesis, new materials and organic chemistry.

    Together we are pursuing research that aims at solving basic olefin metathesis disadvantages to enable its professional industrial use.

    • Anna Kajetanowicz

      Associate leader

      Organic chemistry, metaloenzymes and catalysis specialist

      Anna Kajetanowicz, PHD

    • Anna Rybicka

      Coordinator

      Anna Rybicka, PHD

    • Anupam Jana

      Natural products & organic synthesis specialist

      Anupam Jana, PHD

    • Wojciech Nogaś

      Experienced in crystal engineering & material design

      Wojciech Nogaś, PHD student

    • Michał Patrzałek

      Experienced in graphene and carbonaceous materials

      Michał Patrzałek, PHD student

    • Mariusz Milewski

      Experienced in olefin metathesis and metalorganics

      Mariusz Milewski, PHD student

    • Anna Marczyk

      Experienced in olefin metathesis and metalorganics

      Anna Marczyk, PHD student

    • Students

      • Paweł Krzesiński
      • Aleksandra Zasada
      • Agnieszka Tycz